C. Rohde

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistance

The paper identifies essential RNA modifications in cancer using CRISPR screens and finds that mitochondrial metabolic plasticity influences drug resistance through specific RNA modifications.

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

CloneTracer identifies differentiation routes in AML by adding clonal resolution to single-cell RNA-seq data, revealing disease-defining compartments and therapy response mechanisms.

Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

This paper describes a monoclonal antibody, DZIF-10c, that effectively neutralizes SARS-CoV-2 and its variants when administered intranasally to mice, offering potential for topical treatment.

Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA SARS 2 S in preclinical vaccination

This paper describes the preclinical evaluation of MVA-SARS-2-S, a vector vaccine against SARS-CoV-2, showing it induces immune responses and protects mice from infection.

Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients

This study isolates potent SARS-CoV-2-neutralizing antibodies from COVID-19 patients as early as 8 days post-diagnosis and identifies precursor B cells in healthy individuals.

TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets

This study shows TMPRSS2 and furin are both critical for SARS-CoV-2 activation in human airway cells and that inhibiting them can effectively block virus replication.