MicrobiologybioRxivPreprint
TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets
D. Bestle, M. R. Heindl, H. Limburg…·E. Bottcher-Friebertshauser
This study shows TMPRSS2 and furin are both critical for SARS-CoV-2 activation in human airway cells and that inhibiting them can effectively block virus replication.
DOI 10.1101/2020.04.15.042085