Author

O. Federova

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Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Organism:virus· 1

Frequent Co-Authors

A. Banerjee· 1 shared B. Chait· 1 shared E. A. Campbell· 1 shared G. I. Small· 1 shared H. Molina· 1 shared J. Chandanani· 1 shared P. D. B. Olinares· 1 shared S. A. Darst· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiophysics

A. Banerjee

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1 paper

Recent·Most cited

Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN Domain

G. I. Small, O. Federova, P. D. B. Olinares, J. Chandanani, A. Banerjee, Y. J. Choi, H. Molina, B. Chait, S. A. Darst, E. A. Campbell

This study determines cryo-EM structures of SARS-CoV-2 NiRAN domain catalytic intermediates, revealing structural mechanisms for NMPylation and deRNAylation/capping, and explaining substrate preference for capping.

bioRxiv · Sep 25, 2023Biophysics