B. Chait

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex.

The paper identifies Crm1 as an adaptor that links transcription factors to chromatin at the nuclear pore complex, facilitating enhancer docking.

Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN Domain

This study determines cryo-EM structures of SARS-CoV-2 NiRAN domain catalytic intermediates, revealing structural mechanisms for NMPylation and deRNAylation/capping, and explaining substrate preference for capping.

Distinct Quaternary States, Intermediates, and Autoinhibition During Loading of the DnaB-Replicative Helicase by the Phage {lambda}P Helicase Loader

This study identifies two distinct quaternary states of the DnaB-λP loader complex during DNA replication initiation, revealing structural changes and autoinhibition mechanisms.

Comprehensive Structure and Functional Adaptations of the Yeast Nuclear Pore Complex

This study presents the structure of the yeast nuclear pore complex using cryo-EM, revealing its functional adaptations and evolutionary links.

Immunodominant surface epitopes power immune evasion in the African trypanosome

The paper shows that immune responses to African trypanosome VSGs are focused on immunodominant epitopes, enabling immune evasion through epitope variation.

Analysis of the Mechanosensor Channel Functionality of TACAN

The paper investigates TACAN's functionality as a mechanosensitive ion channel and finds it does not exhibit mechanosensitive activity, instead showing structural features related to fatty acid elongase.

Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

The paper presents cryo-EM structures of the SARS-CoV-2 holo-RdRp complex with nsp13 helicase, revealing interactions and a new therapeutic target.