Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks
O. Heyman, D. Yehezkel, N. Blumberger, G. Rosenberg, C. Ciolli Mattioli, A. Solomon, D. Hoffman, N. Bossel Ben-Moshe, R. Avraham
The paper introduces scPAIR-seq to simultaneously analyze host and bacterial factors during infection, revealing virulence-immune networks in Salmonella Typhimurium.
bioRxiv · Mar 6, 2022Microbiology