R. Avraham

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

Physiological stress drives the emergence of a Salmonella subpopulation through ribosomal RNA regulation

The paper shows that physiological stress in Salmonella leads to a subpopulation with reduced rRNA content, identified through rRNA-FISH and transposon screening.

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks

The paper introduces scPAIR-seq to simultaneously analyze host and bacterial factors during infection, revealing virulence-immune networks in Salmonella Typhimurium.

Bacterial lifestyle switch in response to algal metabolites

This study identifies algal metabolites that drive a bacterial lifestyle switch from coexistence to pathogenicity, highlighting the role of dimethylsulfoniopropionate (DMSP) and benzoate in shaping microbial interactions.

scRNA-seq Reveals A Macrophage Subset That Provides A Splenic Replication Niche For Intracellular Salmonella

The paper uses scRNA-seq to identify a macrophage subset in mice that supports intracellular Salmonella replication in the spleen, revealing a cell-type specific host-pathogen interaction.

A single dose of recombinant VSV-{triangleup}G-spike vaccine provides protection against SARS-CoV-2 challenge

This study develops a recombinant VSV-ΔG-spike vaccine that provides single-dose protection against SARS-CoV-2 in hamsters by inducing neutralizing antibodies and preventing lung pathology.

Antiviral activity of Glucosylceramide synthase inhibitors against SARS-CoV-2 and other RNA virus infections

The study evaluates two GCS inhibitors for antiviral activity against four enveloped RNA viruses, including SARS-CoV-2, showing broad-spectrum efficacy and improved survival in infected mice.