D. Hoffman

Early and Delayed STAT1-Dependent Responses Drive Local Trained Immunity of Macrophages in the Spleen

This study identifies early and delayed STAT1-dependent responses in splenic macrophages that drive trained immunity, enhancing protection against Salmonella Typhimurium infection.

Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks

The paper introduces scPAIR-seq to simultaneously analyze host and bacterial factors during infection, revealing virulence-immune networks in Salmonella Typhimurium.

scRNA-seq Reveals A Macrophage Subset That Provides A Splenic Replication Niche For Intracellular Salmonella

The paper uses scRNA-seq to identify a macrophage subset in mice that supports intracellular Salmonella replication in the spleen, revealing a cell-type specific host-pathogen interaction.

The KSHV ORF20 Protein Interacts With The Viral Processivity Factor ORF59 And Promote Viral Reactivation.

This study identifies ORF20 as a key regulator of KSHV lytic reactivation by interacting with ORF59 and promoting vDNA replication and virion production.