A. Solomon

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

Murine GMP- and MDP-derived classical monocytes have distinct functions and fates

This study identifies distinct functions and fates of murine classical monocytes derived from GMP and MDP, showing differential contributions to tissue macrophage populations.

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks

The paper introduces scPAIR-seq to simultaneously analyze host and bacterial factors during infection, revealing virulence-immune networks in Salmonella Typhimurium.

Inflammatory signals from fatty bone marrow supports the early stages of DNMT3a driven clonal hematopoiesis

This study shows that fatty bone marrow (FBM) promotes DNMT3A-driven clonal hematopoiesis by enhancing inflammatory signals like IL-6, which can be inhibited by blocking the IL-6 receptor.

Uncovering the modified immunopeptidome reveals insights into principles of PTM-driven antigenicity

The paper identifies thousands of novel cancer-specific antigens by analyzing PTMs in immunopeptidomics data from multiple sources and reveals their impact on HLA binding and TCR recognition.

scRNA-seq Reveals A Macrophage Subset That Provides A Splenic Replication Niche For Intracellular Salmonella

The paper uses scRNA-seq to identify a macrophage subset in mice that supports intracellular Salmonella replication in the spleen, revealing a cell-type specific host-pathogen interaction.

Active Trachoma Cases In The Solomon Islands Have Varied Polymicrobial Community Structures But Do Not Associate With Individual Non-Chlamydial Pathogens Of The Eye

The paper investigates whether active trachoma in the Solomon Islands is linked to non-chlamydial pathogens or polymicrobial dysbiosis, finding no significant association with individual pathogens but noting inter-individual microbiome variation.