FGFR3 activating mutations induce luminal-like papillary bladder tumor formation and favor a male gender bias.
M. Shi, A. Moreno-Vega, J. Fontugne, X.-Y. Meng, F. Dufour, A. Kamoun, S. V. Lindskrog, A. Rapinat, C. Dunois-Larde, M.-L. Lapage, E. Chapeaublanc, O. Levrel, T. Lebret, A. Almeida, A. De Reynies, , I. BERNARD-PIERROT
This study shows FGFR3-S249C mutations drive luminal-like papillary bladder tumors in mice and correlate with male gender bias and AR activity in human tumors.
bioRxiv · Sep 2, 2021 · PreprintCancer Biology