M. Shi

Secreted exosomes induce filopodia formation

This study identifies exosomes carrying THSD7A as regulators of filopodia formation in both cancer cells and neurons, mediated through Cdc42 activation.

Uncovering the hidden RNA virus diversity in Lake Nam Co: evolutionary insights from an extreme high-altitude environment

This study identifies 742 RNA virus species in Lake Nam Co, revealing novel viral groups and evolutionary adaptations in an extreme high-altitude environment.

Deciphering the Transcription Factor Landscape in Neuroendocrine Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

This study identifies lineage-specific transcription factor profiles in prostate cancer progression, revealing dynamic shifts during NE transdifferentiation and proposing a three-phase model.

A double-negative prostate cancer subtype is vulnerable to SWI/SNF-targeting degrader molecules

This study identifies a SWI/SNF-targeting therapy effective against a double-negative prostate cancer subtype, showing it reduces viability in both AR-dependent and WNT-dependent models.

Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

This study develops a HSV-vectored therapeutic vaccine that reactivates SIV latency and elicits immune responses, delaying viral rebound in SIV-infected macaques.

Scrutinizing science to save lives: uncovering flaws in the data linking L-type calcium channels blockers to CRAC channels and heart failure.

This paper critiques a study linking L-type calcium channel blockers to heart failure, identifying flaws in methodology, data interpretation, and mathematical analysis.

IOBR2: Multidimensional Decoding Tumor Microenvironment for Immuno-Oncology Research

IOBR2 is a tool for analyzing tumor microenvironment using multi-omics data, offering modules for preprocessing, estimation, interaction analysis, and visualization.

High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia

This study shows high-fat diets worsen endometriosis-related abdominal pain by increasing peritoneal inflammation and pain mediators.

Impact of water deficit on single grapevine berry ripening

This study examines how water deficit affects grapevine berry ripening by analyzing sixteen Vitis vinifera genotypes under varying water conditions, revealing genotype-specific responses in growth and metabolite content.

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

Mechanosensing through talin 1 contributes to tissue mechanical homeostasis

This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

Structural insights into Rad18 targeting by the SLF1 BRCT domains

The paper presents the crystal structure of SLF1tBRCT bound to Rad18 peptide, revealing mechanisms of Rad18 recognition and BRCT-mediated complex assembly.

Novel discovery of a lymphatic bridge connecting Schlemm's canal to limbal and conjunctival lymphatic pathway

The paper discovers a lymphatic bridge connecting Schlemm's canal to limbal and conjunctival lymphatic pathways using advanced imaging techniques in mice.

Using artificial intelligence to document the hidden RNA virosphere

This study uses a deep learning algorithm to discover highly divergent RNA viruses in metatranscriptomes, identifying 161,979 potential species and 180 supergroups.

Alteration of pro-carcinogenic gut microbiota is associated with clear cell renal cell carcinoma tumorigenesis

This study identifies associations between gut microbiota composition and serum metabolites with clear cell renal cell carcinoma, suggesting potential risk factors for tumorigenesis.

Whose energy cost would birds like to save? a revisit of the migratory formation flight

The paper reexamines the energy-saving mechanism in migratory bird formations by considering birds' interests and finds that formation cannot be solely explained by energy optimization.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

Individual bat viromes reveal the co-infection, spillover and emergence risk of potential zoonotic viruses

The study analyzes viral diversity in individual bats to assess co-infection, spillover, and zoonotic risk of potential viruses.

Structural basis for the Rad6 activation by the Bre1 N-terminal domain

The paper presents the crystal structure of the Bre1 RBD-Rad6 complex and shows how their interaction activates Rad6 for H2Bub1 catalysis.

A dual reporter system identifies an intermediate state and sequential regulators of 2-cell-like-to-pluripotent state transition

The paper identifies an intermediate state during 2C-like-to-pluripotent state transition using a dual reporter system and finds key regulators involved in this process.

Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex

This study identifies Arl15 as a regulator of TGFβ signaling by promoting Smad-complex assembly through its interaction with Smad4.

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation

The paper develops a cell-adaptable hydrogel with stem cells to improve spinal cord injury repair by reducing neuroinflammation and enhancing axonal growth in rats.

FGFR3 activating mutations induce luminal-like papillary bladder tumor formation and favor a male gender bias.

This study shows FGFR3-S249C mutations drive luminal-like papillary bladder tumors in mice and correlate with male gender bias and AR activity in human tumors.

Vapor cannabis exposure generationally affects male reproductive functions in mice

This study shows that cannabis vapor exposure in adult male mice reduces sperm count and motility in F0 and F1 generations but not F2, and disrupts spermatogenesis and DNA methylation in F1 testes.

RNA virome diversity and Wolbachia infection in individual Drosophila simulans flies

This study investigates the impact of Wolbachia wAu strain on RNA virome composition in Drosophila simulans and identifies novel viruses in the species.

Integrative analysis of the hydroxypyruvate reductases revealing their distinct roles in photorespiration of Chlamydomonas

The paper identifies and characterizes five hydroxypyruvate reductase genes in Chlamydomonas, revealing distinct enzymatic activities, subcellular locations, and roles in photorespiration.

New metabolic alterations and predictive marker pipecolic acid in sera for esophageal squamous cell carcinoma

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

A Protein A based Staphylococcus aureus vaccine with improved safety

The paper identifies safer variants of Staphylococcal protein A (SpA) to develop clinical-grade vaccines for S. aureus, addressing immune escape mechanisms.