A. Almeida

Aeon: an open-source platform to study the neural basis of ethological behaviours over naturalistic timescales

Aeon enables long-term study of ethological behaviours in mice with simultaneous brain activity recording and provides a unified data format for analysis.

Weak neuronal glycolysis sustains cognition and organismal fitness

This study shows that weak neuronal glycolysis supports cognition and organismal fitness by preventing mitochondrial redox stress and maintaining autophagy.

Dosimetric and biologic intercomparison between electron and proton FLASH beams

This study compares the dosimetric and biological effects of electron and proton FLASH beams in mice, finding similar sparing of brain function and tumor control despite differences in beam type and dose rate.

Development of a Plasmodium vivax biobank for functional ex vivo assays

This study develops an optimized cryopreservation method for Plasmodium vivax isolates and validates its effectiveness for long-term storage and functional assays.

Hypoxic tumors are sensitive to FLASH radiotherapy

This study shows FLASH radiotherapy retains anti-tumor efficacy under extreme hypoxia, overcoming resistance seen with conventional RT.

Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance

This study shows that NCLX in astrocytes affects glycolysis and cognitive performance, with different impacts based on cell type.

FGFR3 activating mutations induce luminal-like papillary bladder tumor formation and favor a male gender bias.

This study shows FGFR3-S249C mutations drive luminal-like papillary bladder tumors in mice and correlate with male gender bias and AR activity in human tumors.

Gel Electrophoresis/Electroelution Sorting Fractionator combined with Filter Aided Sample preparation (FASP) for deep proteomic analysis.

The paper introduces a new device for protein fractionation and demonstrates its effectiveness in increasing protein identification in proteomic analysis.

A mouse model of occult intestinal colonization demonstrating antibiotic-induced outgrowth of carbapenem-resistant Enterobacteriaceae

This study develops a mouse model to study occult colonization and antibiotic-induced outgrowth of carbapenem-resistant Enterobacteriaceae, identifying factors that predict susceptibility to outgrowth.

Functional and taxonomic comparison of mouse and human gut microbiotas using extensive culturing and metagenomics

The paper compares mouse and human gut microbiotas using metagenomics and culturing to identify functional similarities and taxonomic differences.

Host adaptation in gut Firmicutes is associated with sporulation loss and altered colonisation patterns

The paper shows that loss of sporulation in gut Firmicutes is linked to host adaptation, with non-sporulating bacteria being more abundant but less prevalent globally.

Massive expansion of human gut bacteriophage diversity

The paper introduces the Gut Phage Database (GPD), a large collection of gut bacteriophage genomes, and identifies widespread viral diversity and gene flow networks in the human gut.

Phylogenomics of expanding uncultured environmental Tenericutes provides insights into their pathogenicity and evolutionary relationship with Bacilli

This study expands the analysis of uncultured environmental Tenericutes using 840 genomes, revealing their functional patterns, evolutionary relationships with Bacilli, and potential roles in gut microbiome stability.

A unified sequence catalogue of over 280,000 genomes obtained from the human gut microbiome

The paper presents a comprehensive genomic resource of over 280,000 human gut microbiome genomes and their protein sequences, highlighting gaps in functional annotations and genomic diversity.

Mesenchymal Stem/ Stromal Cells metabolomic and bioactive factors profiles: a comparative analysis on the Umbilical Cord and Dental Pulp derived Stem/ Stromal Cells secretome

The paper compares the metabolomic and bioactive factor profiles of secretomes from umbilical cord and dental pulp-derived mesenchymal stem/stromal cells, finding similar overall profiles but distinct dominant factors.

Serological proteomic screening and evaluation of a recombinant egg antigen for the diagnosis of low-intensity infections in endemic area in Brazil

This paper identifies a recombinant egg antigen that improves detection of low-intensity schistosomiasis infections compared to the Kato-Katz method.

Chromosome (mis)segregation is biased by kinetochore size

The paper investigates how kinetochore size affects chromosome segregation in human cells using the Indian muntjac, revealing that larger kinetochores lead to biased segregation outcomes.