Cell BiologybioRxiv
Temporal control of the integrated stress response by a stochastic molecular switch
P. Klein, S. M. Kallenberger, H. Roth…·A. Ruggieri
The paper identifies a stochastic molecular switch controlling the integrated stress response through cooperative activation of PKR, ultrasensitive eIF2 phosphorylation, and negative feedback via GADD34.
DOI 10.1126/sciadv.abk2022