Post-transcriptional gene regulation by the RNA binding protein IGF2BP3 is critical for MLL-AF4 mediated leukemogenesis
T. M. Tran, J. Philipp, J. Bassi, N. Nibber, J. Draper, T. Lin, J. K. Palanichamy, A. K. Jaiswal, O. Silva, M. Paing, J. King, S. Katzman, J. R. Sanford, D. S. Rao
This study identifies IGF2BP3 as a critical regulator of MLL-AF4-driven leukemogenesis, showing its role in enhancing disease progression and identifying it as a potential therapeutic target.
bioRxiv · Dec 20, 2020 · PreprintCancer Biology