T. Lin

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

The paper identifies SNC80 as a drug that reversibly slows metabolism in Xenopus and demonstrates its cross-species applicability in human organs-on-chips and porcine organs.

psudo: Exploring Multi-Channel Biomedical Image Data with Spatially and Perceptually Optimized Pseudocoloring

psudo is an interactive system that optimizes pseudocolor palettes for multichannel biomedical images to enhance perceptual distinction and reduce color confusion in overlapping channels.

Cross-continental variation of herbivore resistance in a global plant invader

The paper examines genetic differentiation in herbivore resistance traits among native and introduced populations of Japanese knotweed across different regions.

How Myosin VI Traps its Off-State, is Activated and Dimerizes

This study investigates how Myosin VI is trapped in its off-state, activated, and dimerizes through structural and functional analyses of its interactions with partners.

Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

Insulin determines the effects of TGF-beta on HNF4alpha transcription and epithelial-to-mesenchymal transition in hepatocytes

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

Cross regulation between the molecular clock and kidney inflammatory, metabolic and fibrotic responses

This study investigates the interaction between the molecular clock and kidney fibrosis in experimental models, finding that clock components influence inflammation and fibrosis, while fibrosis alters clock gene expression.

An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants

This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.

An Essential Role of UBXN3B in B Lymphopoiesis

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.

Post-transcriptional gene regulation by the RNA binding protein IGF2BP3 is critical for MLL-AF4 mediated leukemogenesis

This study identifies IGF2BP3 as a critical regulator of MLL-AF4-driven leukemogenesis, showing its role in enhancing disease progression and identifying it as a potential therapeutic target.

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

Evaluation validation of a qPCR curve analysis method and conventional approaches

The paper evaluates a new qPCR curve analysis method, CqMAN, against existing approaches using clinical and dilution datasets, showing it is comparable and suitable for qPCR data processing.

A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system

This study shows that MSR1 promotes VSV infection in the spinal cord by acting as a receptor, and its absence reduces viral load and mortality in mice.

Effect of thermal and high-pressure processing on the thermo-rheological and functional properties of common bean (Phaseolus vulgaris L.) flours

This study examines how thermal and high-pressure processing affects the functional properties of common bean flours, finding that high-pressure treatment enhances certain properties while thermal treatment reduces others.

STING deficiency-associated aberrant CXCL10 expression contributes to pathogenesis of arthritogenic alphaviruses

This study shows that STING deficiency increases CXCL10 expression, leading to higher viral loads and inflammation in alphavirus-induced arthritis in mice.

The Intergenic Small Non-Coding RNA ittA is Required for Optimal Infectivity and Tissue Tropism in Borrelia burgdorferi

This paper identifies and characterizes ittA, an intergenic sRNA in Borrelia burgdorferi, showing its role in infectivity and tissue tropism through genetic inactivation and transcriptomic/proteomic analyses.

SARS-COV-2 RBD Oral Vaccine Boosted by Mucosal Immune Adjuvant LTB26 via DCs and B Cells Activation in Mice

This paper develops an oral SARS-COV-2 RBD vaccine using LTB26 adjuvant in mice, showing enhanced antibody production and immune activation through DCs and B cells.

A non-canonical histone acetyltransferase targets intragenic enhancers and regulates plant architecture

This study identifies a non-canonical histone acetyltransferase in CYC/TB1-like proteins that regulates plant architecture by modifying histone H3 and activating gene expression.

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

This study characterizes treatment-induced high-grade gliomas (TIHGGs) through molecular profiling, identifying distinct subgroups and potential therapeutic targets.

A simple and sensitive SYBR Gold-based assay to quantify DNA-protein interactions

The paper develops a SYBR Gold-based assay to quantify DNA-protein interactions, showing distinct binding affinities of ARF transcription factors to AuxRE motifs.