J. King

LINC01432 binds to CELF2 in newly diagnosed multiple myeloma promoting short progression-free survival to standard therapy

This study identifies LINC01432 as a lncRNA that binds to CELF2 and inhibits apoptosis in multiple myeloma, contributing to short progression-free survival to standard therapy.

Loss of cell junctional components and matrix alterations drive cell desquamation and fibrotic changes in Idiopathic Pulmonary Fibrosis

The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.

Red knots in Europe - a dead end host species or a new niche for highly pathogenic avian influenza?

A unique HPAIV H5N3 genotype caused mass mortality in red knots in 2020, suggesting red knots may act as a reservoir for the virus.

Chromosome-scale genome assembly of bread wheat's wild relative Triticum timopheevii

This study presents a chromosome-scale genome assembly of Triticum timopheevii using PacBio HiFi and Hi-C data, revealing genomic features and relationships between wheat genomes.

Phenology across scales: an intercontinental analysis of leaf-out dates in temperate deciduous tree communities

The paper analyzes leaf-out variability across temperate deciduous forests in North America and Europe, finding similar intra-community variability despite differences in species richness and environmental conditions.

Pathogen-prey-predator relations of avian raptors during epizootics of highly pathogenic avian influenza virus HPAIV H5N1 (clade 2.3.4.4b) in Germany

The paper investigates the impact of HPAIV H5N1 on avian raptors during epizootics in Germany, finding they act as both indicators of the virus and victims, with mixed outcomes for their population stability.

Cell Surface β-Lactamase Recruitment: A Facile Selection to Identify Protein-Protein Interactions

This paper introduces a method to identify protein-protein interactions by linking them to β-lactamase recruitment on E. coli and ampicillin resistance.

Fluctuations in auxin levels depend upon synchronicity of cell divisions in a one-dimensional model of auxin transport

This paper shows that auxin fluctuations in plant roots arise from asynchronous cell divisions, not periodic signals, and that synchronized divisions can lead to stable oscillations.

NEK1-Mediated Phosphorylation of YAP1 is key to Prostate Cancer Progression

This study identifies NEK1-mediated phosphorylation of YAP1 as critical for prostate cancer progression and shows that inhibiting this pathway can suppress cancer growth and EMT.

Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses

This study shows that amino acid availability regulates ILC2 responses by affecting mTOR activation and expansion, highlighting nutritional cues in innate immunity.

Cold-passaged isolates and bat-swine influenza A chimeric viruses as modified live-attenuated vaccines against influenza A viruses in pigs

This study evaluates modified live-attenuated vaccines against swine influenza A viruses using cold-passaged isolates and bat-swine chimeric viruses, finding that chimeric vaccines are safe and induce protective immunity in pigs.

Identification of Fusarium Head Blight resistance in Triticum timopheevii accessions and characterisation of wheat-T. timopheevii introgression lines for enhanced resistance.

The paper identifies FHB-resistant Triticum timopheevii accessions and shows that introgression of chromosome 3G from these accessions into wheat enhances FHB resistance.

Introgression of the Triticum timopheevii genome into wheat detected by chromosome-specific KASP markers

The paper develops chromosome-specific KASP markers to detect introgression of Triticum timopheevii genome into wheat, identifying extensive recombination with wheat genomes.

A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model

This study evaluates a SARS-CoV-2 Spike ferritin nanoparticle vaccine in cynomolgus macaques, showing strong immunological responses and protection against infection.

The faecal microbiome of the wild European badger Meles meles; a comparison against other wild omnivorous mammals from across the globe

The paper characterizes the faecal microbiome of wild European badgers and compares it to other omnivorous mammals, finding significant species-level diversity differences but no age-related microbiome variation in badgers.

Disentangling the role of poultry farms and wild birds in the spread of highly pathogenic avian influenza virus H5N8 in Europe

This study uses phylodynamic analysis of H5N8 virus sequences to quantify transmission dynamics between poultry farms and wild birds in Europe during the 2016-17 epidemic and identifies key drivers of cross-border spread.

An osmotic laxative renders mice susceptible to prolonged Clostridioides difficile colonization and hinders clearance

This study shows that PEG laxative treatment in mice increases susceptibility to C. difficile colonization and delays clearance.

Post-transcriptional gene regulation by the RNA binding protein IGF2BP3 is critical for MLL-AF4 mediated leukemogenesis

This study identifies IGF2BP3 as a critical regulator of MLL-AF4-driven leukemogenesis, showing its role in enhancing disease progression and identifying it as a potential therapeutic target.

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.

Cytoplasmic sharing through apical membrane remodeling

The paper describes a mechanism in Drosophila rectal papillae where multinucleate cytoplasm is formed through apical membrane remodeling without membrane breaching.

Stoichiometric homeostasis of wetland vegetation along a nutrient gradient in a subtropical wetland. Understanding stoichiometric mechanisms of nutrient retention in wetland macrophytes.

This study examines nutrient homeostasis in wetland vegetation along a nutrient gradient, finding that vegetation is non-homeostatic with respect to nitrogen and phosphorus uptake.

Rapid identification of homozygosity and site of wild relative introgressions in wheat through chromosome-specific KASP genotyping assays

The paper develops chromosome-specific KASP assays to rapidly detect and assess homozygosity of wild relative introgressions in wheat.

Evaluation of nutrient stoichiometric relationships amongst ecosystem compartments of a subtropical treatment wetland. Do we have \"Redfield Wetlands\"?

This study evaluates nutrient stoichiometry in different compartments of subtropical treatment wetlands to assess nutrient cycling and OM decomposition.

Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma

This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.

Non-heritable variation in individual fitness adds stability to neutral theories in ecology and evolution

The paper shows that non-heritable fitness variation stabilizes coexistence in ecological and evolutionary models without requiring niche differentiation.

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

This paper shows that PIKfyve is essential for delivering V-ATPase and proteases to phagosomes, enabling acidification and killing of bacteria, and protecting against Legionella infection.