BiochemistryCell ReportsPeer-reviewed
Activation Mechanism and Structural Assembly of the Mycobacterium tuberculosis ClpP1P2 Protease and Its Associated ATPases.
Katharina Weinhäupl, Tatos N. Akopian, Dmitry A. Semchonok…·Hugo Fraga
This study identifies trehalose as an activator of ClpC1P1P2 and ClpXP1P2 protease complexes in Mycobacterium tuberculosis, revealing a new mechanism for in vivo activation without the need for peptide activators.
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