Hugo Fraga

This study identifies a reversible conformational switch in CdaR's YbbR domains that senses extracellular pH and regulates c-di-AMP signaling in Gram-positive bacteria.

This study identifies trehalose as an activator of ClpC1P1P2 and ClpXP1P2 protease complexes in Mycobacterium tuberculosis, revealing a new mechanism for in vivo activation without the need for peptide activators.

This paper demonstrates a method to overcome the re-protonation bottleneck in NMR by using deuterated cell lysates, enabling high-resolution amide and Hα MAS NMR with improved sensitivity.