Author

Oliver Knowles

MRC Laboratory of Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Assay:imaging· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Ália dos SantosiD· 3 shared Matteo AllegrettiiD· 3 shared Tom DendooveniD· 3 shared Alister BurtiD· 2 shared Piotr KolataiD· 2 shared Thomas Hale· 2 shared Ahmad Reza MehdipouriD· 1 shared Anne F. J. JansseniD· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

Ália dos SantosORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular architecture and spatial organisation of proteasomes in the human sperm nucleus

Piotr Kolata, Ália dos Santos, Oliver Knowles, Tom Dendooven, Matteo Allegretti

This study uses cryo-ET and cryo-EM to reveal the molecular architecture and spatial organisation of proteasomes in human sperm nuclei, identifying unique features and their role in proteolysis.

bioRxiv · Dec 18, 2025 · PreprintCell Biology

In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells

Tom Dendooven, Mina Ebrahimi, Ália dos Santos, Warre Dhondt, Oliver Knowles, Thomas Hale, Alister Burt, Ahmad Reza Mehdipour, Matteo Allegretti

The paper determines the sub-nanometer structure of the SUN5-Nesprin3 LINC complex in human sperm cells, revealing its role in nuclear envelope remodelling and male infertility.

bioRxiv · Aug 4, 2025 · PreprintBiochemistry

Patching up the nucleus: a novel role for PMLII in nuclear envelope rupture repair

Anne F. J. Janssen, Oliver Knowles, Sébastien Britton, Janet Elwyn Deane, Evan Spruijt, Delphine Larrieu

This study identifies PMLII as forming biomolecular condensates at sites of nuclear envelope disruption, suggesting a role in stabilizing the site for repair.

bioRxiv · Jan 24, 2025 · PreprintCell Biology

Human spermatogenesis leads to a reduced nuclear pore structure and function

Ália dos Santos, Oliver Knowles, Tom Dendooven, Thomas Hale, Victoria L. Hale, Alister Burt, Piotr Kolata, Giuseppe Cannone, Dom Bellini, David Barford, Matteo Allegretti

This study investigates the structural and functional changes in human sperm nuclear pore complexes (NPCs) during spermatogenesis, revealing a reduced central channel and altered transport dynamics.

bioRxiv · Oct 30, 2024 · PreprintCell Biology