Ália dos Santos

Molecular architecture and spatial organisation of proteasomes in the human sperm nucleus

This study uses cryo-ET and cryo-EM to reveal the molecular architecture and spatial organisation of proteasomes in human sperm nuclei, identifying unique features and their role in proteolysis.

Paclitaxel compromises nuclear integrity in interphasethrough SUN2-mediated cytoskeletal coupling

This study shows paclitaxel causes nuclear damage in interphase via SUN2-mediated Lamin A/C disruption, revealing an additional mechanism beyond its known mitotic effects.

Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells.

This study shows Myosin VI regulates estrogen receptor activity and gene expression in breast cancer, with MVI inhibition enhancing hormone therapy effectiveness.

Regional patterns of neurodegeneration in a mouse model of proteinopathy

This study maps region-specific histopathological features of scrapie-induced neurodegeneration in mouse brain regions at early and late disease stages, identifying key markers and region-specific mechanisms.

In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells

The paper determines the sub-nanometer structure of the SUN5-Nesprin3 LINC complex in human sperm cells, revealing its role in nuclear envelope remodelling and male infertility.

Human spermatogenesis leads to a reduced nuclear pore structure and function

This study investigates the structural and functional changes in human sperm nuclear pore complexes (NPCs) during spermatogenesis, revealing a reduced central channel and altered transport dynamics.