Author
Broad Institute
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Samuel Maffa, Isabella Boyle, Lie Ward…·Joshua M. Dempster
The paper uses Perturb-seq to analyze gene knockouts in cancer cell lines, identifying context-specific gene dependencies and transcriptional responses.
Marc A. Schwartz, Dillon Lue, Mohammed Mutaher…·Nir Hacohen
The paper identifies Trim28 as a regulator of CD8 T cell differentiation in tumors using clonally-resolved CRISPR screens and shows its role in maintaining TCF7+ stem-like cells while impairing effector differentiation.
Jiaqi Zhang, Marc A. Schwartz, Mohammed Mutaher…·Caroline Uhler
The paper presents a machine learning challenge to predict gene perturbation effects on T cell differentiation, finding that feature representation from perturbational data improves performance and validating top genes experimentally.