Molecular BiologybioRxivPreprint
Autophagy activator AA-20 engages CDK5 to promote lipophagy and improve neurodegeneration-associated phenotypes
Ee Phie Tan, Lydia Ambaye, Anne-Laure Mahul-Mellier…·Jeffery W. Kelly
AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.