Author

Owen Underwood

Nottingham Contemporary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1

Frequent Co-Authors

Stephen J. BriddoniD· 2 shared Arisbel B. GondiniD· 1 shared Armin Nikpour Khoshgrudi· 1 shared Carsten HoffmanniD· 1 shared Clare R. HarwoodiD· 1 shared Colin Nicholson· 1 shared David A. SykesiD· 1 shared Dmitry B. VeprintseviD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPharmacology & Toxicology

Stephen J. BriddonORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyFrontiers in PharmacologyPeer-reviewedMar 27, 2025

Agonist efficacy at the B2AR is driven by agonist-induced differences in receptor affinity for the Gs protein, not ligand binding kinetics.

Clare R. Harwood, David A. Sykes, Theo Redfern-Nichols…·Dmitry B. Veprintsev

This study shows that agonist efficacy at the {beta}2AR is determined by differences in receptor affinity for Gs protein, not ligand binding kinetics.

5 citations

humanproteomics

𝕏 PostBluesky

Pharmacology & ToxicologyCommunications BiologyPeer-reviewedAug 2, 2024

Key phosphorylation sites for robust β-arrestin2 binding at the mu-opioid receptor revisited

Owen Underwood, Sebastian Fritzwanker, Jaqueline Glenn…·Meritxell Canals

The paper investigates the role of GRK subfamilies in phosphorylation of the MOR C-tail and their impact on β-arrestin2 recruitment, showing GRK2/3 and GRK5/6 have distinct contributions.

22 citations

humanproteomics

𝕏 PostBluesky