ImmunologybioRxiv
The cyclic dinucleotide 2'3'-cGAMP induces a broad anti-bacterial and anti-viral response in the sea anemone Nematostella vectensis
S. R. Margolis, P. A. Dietzen, B. M. Hayes…·R. E. Vance
This study shows that 23-cGAMP induces both anti-viral and anti-bacterial gene expression in the sea anemone Nematostella vectensis, suggesting an ancestral role for cyclic dinucleotide signaling in immunity.
DOI 10.1073/pnas.2109022118