Author

P. A. Humphries

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Biochemistry· 1

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Approach:biophysical modeling· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. E. van Vlimmeren· 1 shared C. A. Chartier· 1 shared D. Karandur· 1 shared N. H. Shah· 1 shared R. Voleti· 1 shared W.-L. Lo· 1 shared Z. Jiang· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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1 shared paperBiochemistry

A. E. van Vlimmeren

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1 paper

Recent·Most cited

BiochemistrybioRxivJul 10, 2023

The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain

A. E. van Vlimmeren, R. Voleti, C. A. Chartier…·N. H. Shah

This paper investigates the T42A mutation in SHP2, showing it alters ligand-binding specificity in the N-terminal SH2 domain, leading to biased activation and enhanced signaling.

DOI 10.1073/pnas.2407159121

humanproteomics

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