Author

D. Karandur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Approach:biophysical modeling· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. Kuriyan· 3 shared N. H. Shah· 2 shared A. E. van Vlimmeren· 1 shared A. Merk· 1 shared C. A. Chartier· 1 shared C. J. Huang· 1 shared D. Lee· 1 shared D. Wemmer· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

J. Kuriyan

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Author profile →

4 papers

Recent·Most cited

The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain

A. E. van Vlimmeren, R. Voleti, C. A. Chartier, Z. Jiang, D. Karandur, P. A. Humphries, W.-L. Lo, N. H. Shah

This paper investigates the T42A mutation in SHP2, showing it alters ligand-binding specificity in the N-terminal SH2 domain, leading to biased activation and enhanced signaling.

bioRxiv · Jul 10, 2023Biochemistry

A Saturation-Mutagenesis Analysis of the Interplay Between Stability and Activation in Ras

F. Hidalgo, L. M. Nocka, N. H. Shah, K. Gorday, N. R. Latorraca, P. Bandaru, S. Templeton, D. Lee, D. Karandur, J. G. Pelton, S. Marqusee, D. Wemmer, J. Kuriyan

This study shows that cancer hotspot mutations in Ras activate it regardless of stability, while non-hotspot mutations can be activating or deleterious depending on stability.

bioRxiv · Jan 6, 2022Biophysics

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

Y. Huang, J. Ognjenovic, D. Karandur, K. Miller, A. Merk, S. Subramaniam, J. Kuriyan

This study identifies how EGFR differentiates signaling outputs from EGF and TGF- through conformational changes in its extracellular domain.

bioRxiv · Dec 8, 2020Biochemistry

CRISPR-Cas12a exploits R-loop asymmetry to form double strand breaks

J. C. Cofsky, D. Karandur, C. J. Huang, I. P. Witte, J. Kuriyan, J. A. Doudna

This study shows that Cas12a uses R-loop asymmetry to cut the second DNA strand without direct protein interaction, explaining its double-strand break mechanism.

bioRxiv · Feb 10, 2020Biochemistry