P53-independent restoration of p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9
X. Tian, N. Ahsan, A. Lulla, A. Lev, P. Abbosh, D. Dicker, S. Zhang, W. El-Deiry
PG3-Oc restores p53 pathway signaling in mutant-p53 tumors through ATF4 modulation by ERK1/2 and CDK9, inducing p53 effector genes for cell death and tumor suppression.
bioRxiv · Oct 20, 2020Cancer Biology