Suppression of autoimmune arthritis and neuroinflammation via an amino acid-conjugatedbutyrate prodrug with enhanced oral bioavailability
S. Cao, E. Budina, M. M. Raczy, A. Solanki, M. Nguyen, T. N. Beckman, J. W. Reda, K. Hultgren, P. Ang, A. J. Slezak, L. A. Hesser, A. T. Alpar, K. C. Refvik, L. S. Shores, I. Pillai, , J. A. Hubbell
This study develops a butyrate prodrug, SerBut, which improves oral bioavailability and reduces autoimmune arthritis and neuroinflammation in mouse models.
bioRxiv · Apr 28, 2023 · PreprintBioengineering