S. Cao

Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress

This study reveals how two F-box proteins, FBXO22 and FBXL17, recognize distinct structural features of the BACH1 BTB dimer under oxidative stress, leading to its ubiquitination and degradation.

Engineered Flt3L Drives Tolerogenic State to Attenuate Anti-drug Antibody Responses

The paper describes a method using engineered Flt3L to induce a tolerogenic immune state, reducing anti-drug antibodies to a fungal enzyme.

Blockade of TREM2 ameliorates pulmonary inflammation and fibrosis by modulating sphingolipid metabolism

This study shows that blocking TREM2 reduces pulmonary inflammation and fibrosis by altering sphingolipid metabolism and chemokine expression in macrophages.

Exploratory study of pulsed electric field ablation on atherosclerotic plaque in a rabbit model

This study investigates pulsed electric field ablation's effects on atherosclerotic plaques in rabbits, finding reduced lipid deposition, vascular remodeling, and increased elasticity.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

Genome analyses reveal the secondary metabolites potentially influence the geographical distribution of Fusarium pseudograminearum populations

This study analyzes genomes of Fusarium pseudograminearum strains to show that secondary metabolite synthesis genes influence their geographical distribution and toxin production.

Injectable butyrate-prodrug micelles induce long-acting immune modulation and suppress autoimmune arthritis in mice

This study develops butyrate-prodrug micelles that target lymphatics to induce long-term immune modulation and reduce arthritis in mice.

Suppression of autoimmune arthritis and neuroinflammation via an amino acid-conjugatedbutyrate prodrug with enhanced oral bioavailability

This study develops a butyrate prodrug, SerBut, which improves oral bioavailability and reduces autoimmune arthritis and neuroinflammation in mouse models.

Glycosylation-modified antigens as an inverse vaccine platform prevent anaphylaxis in a pre-clinical model of food allergy

This paper develops a glycosylation-modified antigen vaccine platform that prevents anaphylaxis in a cow's milk allergy mouse model by inducing antigen-specific non-responsiveness.

LDHA maintains the growth and migration of vascular smooth muscle cells and promotes neointima formation via crosstalk between K5 crotonylation and K76 mono-ubiquitination

This study identifies how LDHA regulates VSMC growth and migration through K5 crotonylation and K76 mono-ubiquitination, promoting neointima formation in injured arteries.

Metabolomics reveals nucleoside analogs for regulating mucosal-associated invariant T cell responses

The paper identifies nucleoside analogs from Mycobacterium tuberculosis that regulate MAIT cell activation, revealing conserved ligands across bacterial and mammalian systems.

Extreme diversity of mycoviruses present in four strains of Rhizoctonia cerealis, the pathogen of wheat sharp eyespot

The paper analyzes viral genomes from four strains of Rhizoctonia cerealis, identifying 131 novel or unclassified mycoviruses and proposing new taxonomic classifications.

Building insightful, memory-enriched models to capture long-time biochemical processes from short-time simulations

This paper introduces a memory-enriched model using TCL-GME to efficiently capture long-time biochemical dynamics from short simulations, reducing data requirements and improving accuracy.

Asparagine starvation suppresses histone demethylation through iron depletion

This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.

Bioprinting microporous functional living materials from protein-based core-shell microgels

This paper introduces a core-shell microgel bioprinting method to create functional living materials with controlled microporosity and enhanced bioprocessing capabilities.

Microbial metabolite butyrate-prodrug polymeric micelles demonstrate therapeutic efficacy in pre-clinical models of food allergy and colitis

The paper develops butyrate-prodrug polymeric micelles that restore gut barrier function and reduce inflammation in pre-clinical models of food allergy and colitis.

Glutamine is essential for overcoming theimmunosuppressive microenvironment in malignant salivary gland tumors

This study shows that dietary glutamine supplementation enhances antitumor immunity by altering the tumor microenvironment in mice with malignant salivary gland tumors.

Calcineurin-fusion facilitates Cryo-EM Structure Determination of a Family A GPCR

This paper describes a method using calcineurin fusion to improve cryo-EM structure determination of Family A GPCRs by enhancing particle alignment.

Bacterial lipopolysaccharide induces settlement and metamorphosis in a marine larva

This study identifies lipopolysaccharide (LPS) from the bacterium Cellulophaga lytica as the inducer of metamorphosis in Hydroides elegans larvae, suggesting LPS may be a widespread cue for bacterial-induced settlement in marine invertebrates.

Engineered collagen-targeting therapeutics reverse lung and kidney fibrosis in mice

This study develops collagen-targeted therapeutics that reduce lung and kidney fibrosis in mice by improving drug delivery and efficacy.

A poxvirus decapping enzyme localizes to mitochondria to regulate RNA metabolism and translation, and promote viral replication

This study identifies vaccinia virus D10 as a mitochondria-localized decapping enzyme that promotes viral replication by preferentially targeting cellular mRNAs for decapping and enhancing viral mRNA translation.

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

This study shows that Zika virus causes placental pyroptosis via GSDME activation, leading to adverse fetal outcomes.

Aberrant epigenetic and transcriptional events associated with breast cancer risk

This study identifies molecular aberrations in normal breast tissue from high-risk women, linking epigenetic and transcriptional changes to breast cancer susceptibility.

Neuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLC

This study shows SCLC cells mimic neurons to promote brain metastasis by recruiting astrocytes through factors like Reelin and SERPINE1.

RPnet: A Reverse Projection Based Neural Network for Coarse-graining Metastable Conformational States for Protein Dynamics

This paper introduces RPnet, a neural network method for coarse-graining metastable conformational states in protein dynamics, showing comparable or better results than existing methods.

Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets in vivo

This study uses transcranial photoacoustic imaging to detect early-stage photothrombotic stroke in neonatal piglets, finding that HbO2 saturation can distinguish affected from control brain regions.

Multi-Level DBSCAN: A Hierarchical Density-Based Clustering Method for Analyzing Molecular Dynamics Simulation Trajectories

This paper introduces ML-DBSCAN, a hierarchical clustering method for MD simulations, which identifies metastable states and free energy landscapes at multiple resolutions.

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

This paper demonstrates that conjugating the SARS-CoV-2 Spike protein to a polymeric glyco-adjuvant elicits strong cellular and humoral immune responses in mice.

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity

This study develops a subunit nanovaccine using polymersomes decorated with SARS-CoV-2 RBD, showing enhanced neutralizing antibody and T cell responses in mice.