Extracellular matrix flow guides in-vitro epithelial morphogenesis
A. R. A. Fattah, F. Sgualdino, S. Poovathingal, K. Davie, P. Baatsen, K. Vints, N. Gunko, A. Ranga
The paper shows ECM flow drives epithelial morphogenesis in hPSC monolayers through directional movement and local symmetry breaking, validated by in silico modeling and scRNAseq.
bioRxiv · Oct 21, 2022 · PreprintBioengineering