Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease
S. Boeynaems, X. R. Ma, V. Yeong, G. M. Ginell, J.-H. Chen, J. A. Blum, L. Nakayama, A. Sanyal, A. Briner, D. Van Haver, J. Pauwels, A. Ekman, H. B. Schmidt, K. Sundararajan, L. Porta, , A. D. Gitler
The paper identifies a common toxic mechanism in positively charged peptides across species and develops a machine learning tool to detect it.
bioRxiv · Mar 9, 2023 · PreprintCell Biology