S. Jacobs

Residual cohesin function and PARP1 levels determine PARP inhibitor sensitivity in STAG2-deficient cancers

This study identifies residual cohesin function and PARP1 levels as key factors determining PARP inhibitor sensitivity in STAG2-deficient cancers, highlighting the need for biomarker-based patient stratification.

Depletion of skin bacteria by topical antibiotic treatment accelerates onset of Zika virus disease in mice.

This study shows that topical antibiotics reduce skin bacteria in mice, leading to faster Zika virus disease progression and higher viral loads in multiple tissues.

Perturbation of alphavirus and flavivirus infectivity by components of the bacterial cell wall

This study shows that bacterial cell wall components reduce alphavirus and flavivirus infectivity by directly interacting with viral particles in vitro.

High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage

This study compares transmissibility and pathogenicity of recent African and Asian Zika virus strains, finding African strains more transmissible, lethal, and capable of causing fetal death.

Antiviral treatment of SARS-CoV-2-infected hamsters reveals a weak effect of favipiravir and a complete lack of effect for hydroxychloroquine

This study evaluates the antiviral effects of favipiravir and hydroxychloroquine in SARS-CoV-2-infected hamsters, finding limited efficacy for both drugs.

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

This study shows that STAT2 signaling both restricts SARS-CoV-2 spread and causes severe pneumonia in infected hamsters.

Microscaled Proteogenomic Methods for Precision Oncology

This study develops microscaled proteogenomic methods for cancer analysis, showing treatment response and resistance mechanisms in ERBB2-positive breast cancers.

Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages

The paper shows that activating innate immune responses at the mosquito bite site, specifically targeting skin-resident macrophages, can inhibit systemic arbovirus dissemination and improve clinical outcomes.