Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2
I. D. Jana, P. Bhttacharya, K. Mayilsamy, S. Banerjee, G. Bhattacharje, S. Das, S. Aditya, A. Ghosh, A. R. McGill, S. Srikrishnan, A. K. Das, A. Basak, S. S. Mohapatra, B. Chandran, D. Bhimsaria, , A. Mondal
This study identifies an evolutionarily conserved 'E-L-L' motif in the SARS-CoV-2 spike protein as a target for small molecule fusion inhibitors, showing posaconazole effectively blocks viral entry across variants.
bioRxiv · Mar 16, 2022Biochemistry