BiochemistrybioRxiv
Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2
I. D. Jana, P. Bhttacharya, K. Mayilsamy…·A. Mondal
This study identifies an evolutionarily conserved 'E-L-L' motif in the SARS-CoV-2 spike protein as a target for small molecule fusion inhibitors, showing posaconazole effectively blocks viral entry across variants.
DOI 10.1093/pnasnexus/pgac198