Author

P. Brest

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. Carminati· 1 shared A. Hubstenberger· 1 shared B. Mari· 1 shared B. Mograbi· 1 shared B. Romeo· 1 shared C. Bontoux· 1 shared C. Lacoux· 1 shared C. Savy· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Carminati

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Author profile →

2 papers

Recent·Most cited

Disrupting USP39 deubiquitinase Function Impairs the Survival and Migration of Multiple Myeloma Cells through ZEB1 Degradation

J. Sirera, S. Sarlak, M. Teisseire, A. Carminati, C. Savy, V. Nicolini, P. Brest, C. Bontoux, M. Deckert, M. Ohanna, S. GIULIANO, M. Dufies, G. Pages, F. Luciano

This study identifies USP39 as a critical survival and migration factor in multiple myeloma cells, showing that its disruption leads to ZEB1 degradation and reduced tumor growth.

bioRxiv · Apr 23, 2024 · PreprintCancer Biology

Processing body dynamics drive non-genetic MEK inhibitors tolerance by fine-tuning KRAS and NRAS translation

O. Vidal-Cruchez, V. J. Nicolini, T. Rete, R. Rezzonico, C. Lacoux, J. Fassy, K. Jacquet, M. A. Domdom, C. Ventujol, T. Juhel, B. Romeo, J. Roux, A. Hubstenberger, B. Mari, B. Mograbi, , P. Brest

The paper identifies a mechanism where MEK inhibitors induce tolerance by promoting KRAS and NRAS translation via PB dissolution, revealing a dynamic feedback loop in MAPK signaling.

bioRxiv · Dec 6, 2021 · PreprintCancer Biology