Cancer BiologybioRxivPreprint
Processing body dynamics drive non-genetic MEK inhibitors tolerance by fine-tuning KRAS and NRAS translation
O. Vidal-Cruchez, V. J. Nicolini, T. Rete…·P. Brest
The paper identifies a mechanism where MEK inhibitors induce tolerance by promoting KRAS and NRAS translation via PB dissolution, revealing a dynamic feedback loop in MAPK signaling.
DOI 10.1101/2021.12.06.471470