M. Deckert

Disrupting USP39 deubiquitinase Function Impairs the Survival and Migration of Multiple Myeloma Cells through ZEB1 Degradation

This study identifies USP39 as a critical survival and migration factor in multiple myeloma cells, showing that its disruption leads to ZEB1 degradation and reduced tumor growth.

Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma

This study identifies the miR-143/-145 cluster as a driver of therapy-resistant mesenchymal-like phenotype in melanoma and shows that blocking its pro-fibrotic effects enhances MAPK inhibitor efficacy.

Invasive dedifferentiated melanoma cells inhibit JAK1-STAT3-driven actomyosin contractility of human fibroblastic reticular cells of the lymph node

The paper shows that dedifferentiated melanoma cells inhibit FRC contractility via JAK1-STAT3 and YAP pathways, reducing actomyosin forces and promoting LN remodeling.

Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy

This study shows that targeting DDR1 and DDR2 overcomes matrix-mediated resistance to BRAF inhibitors in melanoma by disrupting ECM-driven survival pathways.

Electrochemical Roughening and Carbon Nanotube Coating of Tetrodes for Chronic Single-Unit Recording

This paper develops a tetrode probe with electrochemical roughening and carbon nanotube coating to enable long-term, high-quality single-unit recordings in rodent and primate brains.