Author

P. Brian Hardy

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Research Focus:benchmarking· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Eric M. MerteniD· 3 shared Kenneth H. PearceiD· 3 shared Brandon NovyiD· 2 shared Devan J. ShelliD· 2 shared Ivanna ZhilinskayaiD· 2 shared Jacqueline L. Norris-DrouiniD· 2 shared James WellnitziD· 2 shared Konstantin I. PopoviD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioinformatics

Eric M. MertenORCID

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3 papers

Recent·Most cited

BioinformaticsJournal of CheminformaticsPeer-reviewedSep 4, 2026

Open-Source DNA-Encoded Library Package for Design, Decoding, and Analysis: DELi

James Wellnitz, Brandon Novy, Shu-Hang Lin…·Konstantin I. Popov

DELi is an open-source platform for DNA-encoded library design, decoding, and analysis, demonstrating its effectiveness through the identification of a BRD4 binder.

3 citationstop 2%

DNA methylationexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintSep 30, 2025

Expansion of DNA-Encoded Library Hits Using Generative Chemistry and Ultra-Large Compound Catalogs

Brandon Novy, Shu-Hang Lin, Devan J. Shell…·Konstantin I. Popov

This paper combines DNA-encoded libraries with generative AI to expand hit compounds, finding AI-selected hits show better drug-likeness and diversity than initial DEL hits.

DOI 10.1101/2025.09.30.679600

deep learningdrug response / drug discovery

𝕏 PostBluesky

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedOct 10, 2024

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

Eric M. Merten, John D. Sears, Tina M. Leisner…·Kenneth H. Pearce

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

42 citationstop 1%

comparative / phylogenetic analysisdrug response / drug discovery

𝕏 PostBluesky