Author
University of North Carolina at Chapel HillORCID 0000-0002-9181-3431Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
James Wellnitz, Brandon Novy, Shu-Hang Lin…·Konstantin I. Popov
DELi is an open-source platform for DNA-encoded library design, decoding, and analysis, demonstrating its effectiveness through the identification of a BRD4 binder.
Brandon Novy, Shu-Hang Lin, Devan J. Shell…·Konstantin I. Popov
This paper combines DNA-encoded libraries with generative AI to expand hit compounds, finding AI-selected hits show better drug-likeness and diversity than initial DEL hits.
Holli‐Joi Martin, Mohammad Anwar Hossain, James Wellnitz…·Alexander Tropsha
The paper curates a database of helicase inhibitors, Heli-SMACC, and tests selected compounds against SARS-CoV-2 NSP13 ATPase, finding twelve inhibitors with dose-response activity.
Kesatebrhan Haile Asressu, Jeffery L. Smith, Rebekah J. Dickmander…·Timothy Mark Willson
The paper synthesizes pyrimidoquinoline derivatives as CSNK2A inhibitors with antiviral activity, finding that certain substituents improve potency while maintaining solubility.