Suppression of systemic T cell immunity to viral infection during liver injury is prevented by inhibition of interferon and IL-10 signaling
P. C. Hackstein, J. Spitzer, K. Symeonidis, H. Horvatic, T. Bedke, B. Steglich, L. Assmus, A. Odainic, N. Kessler, S. Klein, M. Beyer, R. Schmithausen, E. Latz, C. Kurts, J. Trebicka, , Z. Abdullah
The paper shows that liver injury suppresses systemic T cell immunity to viral infection, which can be reversed by inhibiting interferon and IL-10 signaling in preclinical models and human patients.
bioRxiv · Jul 21, 2022 · PreprintImmunology