Z. Abdullah

Multiple clustered centrosomes in antigen-presenting cells foster T cell activation without MTOC polarization

This study shows that multiple clustered centrosomes in antigen-presenting cells enhance T cell activation by positioning near the cell center, unlike T cells where centrosomes polarize toward the immune synapse.

Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

β1 integrin signaling governs necroptosis via the chromatin remodeling factor CHD4

The paper shows that β1 integrin signaling regulates necroptosis through CHD4-mediated repression of Ripk3 in fibrosis.

Epigenetic regulation of innate immune genes and enhanced interleukin-10 expression underlie chronic subclinical Plasmodium chabaudi infection

This study identifies epigenetic regulation of innate immune genes and increased IL-10 expression as mechanisms underlying chronic subclinical Plasmodium chabaudi infection in mice.

Suppression of systemic T cell immunity to viral infection during liver injury is prevented by inhibition of interferon and IL-10 signaling

The paper shows that liver injury suppresses systemic T cell immunity to viral infection, which can be reversed by inhibiting interferon and IL-10 signaling in preclinical models and human patients.