Author

A. Roers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 7 Research Focus:cell type annotation· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:development & morphogenesis· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2

Frequent Co-Authors

A. Gerbaulet· 5 shared R. Behrendt· 4 shared Y. Ge· 4 shared A. Dahl· 3 shared C. M. Munz· 2 shared L. Muhandes· 2 shared M. N. F. Morcos· 2 shared N. Dressel· 2 shared

Activity by Year

2019-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersCell Biology

A. Gerbaulet

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Emergency hematopoiesis proceeds without contribution of hematopoietic stem cells

C. M. Munz, N. Dressel, M. Chen, T. Grinenko, A. Roers, A. Gerbaulet

This study shows that hematopoietic stem cells (HSCs) do not contribute to mature blood cell regeneration during common emergencies like inflammation or blood loss.

bioRxiv · Oct 5, 2022Cell Biology

Suppression of systemic T cell immunity to viral infection during liver injury is prevented by inhibition of interferon and IL-10 signaling

P. C. Hackstein, J. Spitzer, K. Symeonidis, H. Horvatic, T. Bedke, B. Steglich, L. Assmus, A. Odainic, N. Kessler, S. Klein, M. Beyer, R. Schmithausen, E. Latz, C. Kurts, J. Trebicka, , Z. Abdullah

The paper shows that liver injury suppresses systemic T cell immunity to viral infection, which can be reversed by inhibiting interferon and IL-10 signaling in preclinical models and human patients.

bioRxiv · Jul 21, 2022 · PreprintImmunology

Slow integrin-dependent migration organizes networks of tissue-resident mast cells

S. K. Bambach, L. Kaltenbach, N. Aizarani, P. Martzloff, A. Gavrilov, K. M. Glaser, R. Thünauer, M. Mihlan, M. Stecher, A. Thiriot, S. Wienert, U. H. von Andrian, M. Schmidt-Supprian, C. Nerlov, F. Klauschen, , T. Lämmermann

This study shows that mast cells use slow integrin-dependent migration to form tissue networks, differing from other leukocytes that use fast adhesion-free movement.

bioRxiv · Jul 19, 2022 · PreprintCell Biology

Clearance of genome-damaged cells from the hematopoietic system via p53 without contribution by the cGAS/STING axis

N. Dressel, L. Natusch, C. Munz, S. Costas-Ramon, M. N. F. Morcos, A. Loff, B. Hiller, H. Luksch, A. Roesen-Wolff, A. Roers, R. Behrendt, A. Gerbaulet

This study shows that p53 clears genome-damaged hematopoietic cells without needing the cGAS/STING pathway, and that cGAS/STING is not required for coping with DNA damage or preventing leukemia in RER-deficient conditions.

bioRxiv · Jun 24, 2022 · PreprintCell Biology

Validation of an RNase H2 activity assay suitable for clinical screening

M. S. Schulz, C. Guenther, R. Behrendt, A. Roers

The paper validates a FRET-based assay for measuring RNase H2 activity in clinical samples, showing it can detect reduced activity in patient lymphocytes.

bioRxiv · Jun 9, 2022 · PreprintImmunology

cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNA

T. Schumann, S. C. Ramon, N. Schubert, M. A. Mayo, M. Hega, S.-R. Ada, L. Sydow, M. Hajikazemi, Y. Ge, M. Badstübner, S. Lienenklaus, B. Utess, L. Muhandes, M. Haase, L. Müller, , R. Behrendt

The paper shows that loss of SAMHD1 leads to chronic DNA damage and cGAS/STING-dependent type I interferon production in mice, linking it to autoimmunity and cancer.

bioRxiv · May 16, 2022Immunology

Predictive framework of macrophage activation

D. E. Sanin, Y. Ge, E. Marinkovic, A. M. Kabat, A. Castoldi, G. Caputa, K. M. Grzes, J. D. Curtis, S. Willenborg, S. Dichtl, S. Reinhardt, A. Dahl, E. L. Pearce, S. A. Eming, A. Gerbaulet, , E. J. Pearce

The paper establishes a common framework for macrophage activation by identifying conserved transcriptional profiles across tissues and conditions.

bioRxiv · Aug 2, 2021Immunology

Filaggrin deficient mice have a lower threshold for cutaneous allergen sensitization but do not develop spontaneous skin inflammation or atopy

L. Muhandes, M. Pippel, M. Chapsa, R. Behrendt, Y. Ge, A. Dahl, B. Yi, A. Dalpke, S. Winkler, M. Hiller, S. Beissert, R. Jessberger, P. G. Fallon, A. Roers

This study shows that Flg-deficient mice do not develop spontaneous skin inflammation or atopy, but Flg deficiency may modulate dermatitis caused by other barrier defects.

bioRxiv · Sep 11, 2020 · PreprintImmunology

Proliferative behavior of hematopoietic stem cells revisited: No evidence for mitotic memory

M. N. F. Morcos, T. Zerjatke, I. Glauche, C. M. Munz, Y. Ge, A. Petzold, S. Reinhardt, A. Dahl, N. Anstee, R. Bogeska, M. Milsom, P. Saewen, H. Wan, D. Bryder, A. Roers, A. Gerbaulet

The paper revisits the proliferative behavior of hematopoietic stem cells (HSCs) and finds no evidence for mitotic memory or permanent quiescence after few divisions.

bioRxiv · Aug 28, 2019Cell Biology