GCN5L1 promotes diastolic dysfunction by inhibiting cardiac pyruvate oxidation
D. Thapa, P. Bugga, B. A. S. Mushala, J. R. Manning, M. W. Stoner, B. McMahon, X. Zeng, P. Cantrell, N. Yates, B. Xie, L. R. Edmunds, M. J. Jurczak, I. Scott
This study identifies GCN5L1 as a regulator of cardiac pyruvate oxidation, showing its role in promoting diastolic dysfunction through inhibition of PDH complex acetylation in aged obese mice.
bioRxiv · Sep 7, 2021 · PreprintPhysiology