B. Xie

A Universal, Single-Component Multilayered Self-Assembling Protein Nanoparticle Vaccine Based on Extracellular Domains of Matrix Protein 2 Against Both Influenza A and B

This paper develops a single-component self-assembling nanoparticle vaccine targeting conserved M2e domains from both influenza A and B viruses, showing 100% protection against H1N1 and 70% against Yamagata lineage influenza B in mice.

Suppression of T cell function by phosphoethanolamine, a metabolite enriched in tumor interstitial fluid

This study identifies phosphoethanolamine as a key metabolite in tumor interstitial fluid that suppresses T cell function by inhibiting TCR signaling.

Jagged-1+ Tregs Mediate Lymphatic Remodeling in Tumour-Draining Lymph Nodes

This study shows that Jag1-expressing regulatory T cells (Tregs) in tumor-draining lymph nodes (tdLNs) are essential for lymphatic remodeling and niche formation during melanoma progression.

Locally released somatostatin triggers cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function

This study shows that somatostatin acting on primary cilia of pancreatic β-cells modulates cAMP and Ca2+ signaling, affecting β-cell function and linking cilia length to type-2 diabetes.

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

Enhanced Antibody Response to the Conformational Non-RBD Region via DNA Prime-Protein Boost Elicits Broad Cross-Neutralization Against SARS-CoV-2 Variants

This study shows that DNA prime-protein boost elicits enhanced antibodies against non-RBD regions of SARS-CoV-2, improving cross-neutralization against variants in mice.

Intraspecies interactions of Streptococcus mutans impact biofilm architecture and virulence determinants in childhood dental caries

This study investigates how intraspecies interactions between Streptococcus mutans strains affect biofilm properties and virulence in early childhood dental caries using in vitro and in vivo models.

SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling

This study identifies SARS-CoV-2 NSP13 as a suppressor of Hippo-YAP signaling by interacting with TEAD and remodeling chromatin to inhibit YAP transcriptional activity.

The Host-specific Microbiota is Required for Diet-Specific Metabolic Homeostasis

This study shows that host-specific microbiota are essential for maintaining diet-specific metabolic homeostasis, while foreign microbiota impair metabolic fitness in germ-free mice.

Early life regulatory T cells modulate PPAR-gamma dependent skin pigmentation

The paper shows that early life regulatory T cells (ETregs) regulate PPAR-gamma signaling in hair follicles, which is essential for melanocyte stem cell-mediated skin pigmentation.

Exploring the tumor micro-environment in ovarian cancer histotypes and tumor sites

This study uses single-cell RNA sequencing to analyze ovarian cancer histotypes and tumor sites, identifying cell compositions, marker genes, and ligand-receptor pairs in the tumor microenvironment.

The molecular mechanism of positive allosteric modulation at the dopamine D1 receptor

This study investigates the molecular mechanism of LY3154207's positive allosteric modulation at the dopamine D1 receptor using cryo-EM structures and molecular dynamics simulations.

Strengthening E-cadherin adhesion via antibody mediated binding stabilization.

This study identifies how the monoclonal antibody 66E8 stabilizes E-cadherin adhesion by stabilizing the strand-swap dimer conformation through electrostatic interactions.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

Does the territorial behaviour of the Amur tiger affect the accuracy of occupancy estimation?

This study develops a modified occupancy model to distinguish true-presence from pseudo-presence in Amur tigers, improving occupancy estimation accuracy by accounting for territorial behavior.

Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model

The paper shows fast-food diets cause gut microbiota imbalances that predict and drive NAFLD progression in mice, with effects seen in conventionally-raised but not germ-free mice.

Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons

This study uses multiplex epigenome editing to reactivate MECP2 from the inactive X chromosome in RTT neurons, rescuing neuronal defects in vitro.

G-PROTEIN COUPLED RECEPTOR 19 (GPR19) KNOCKOUT MICE DISPLAY SEX-DEPENDENT METABOLIC DYSFUNCTION

This study shows that GPR19 knockout mice exhibit sex-dependent metabolic dysfunction, with males showing glucose intolerance and liver enlargement on a high-fat diet.

A molecular mechanism for membrane chaperoning by a late embryogenesis abundant protein

This paper identifies HeLEA1, a tardigrade LEA protein that acts as a mitochondrial membrane chaperone, improving stress tolerance in yeast by stabilizing lipid packing and reducing surface tension.

An interaction between betaprime-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling

This study identifies the interaction between betaprime-COP and Glo3, an ArfGAP, showing it is essential for post-Golgi cargo recycling in yeast.

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

This study identifies how the monoclonal antibody 19A11 strengthens E-cadherin adhesion through a salt bridge that stabilizes the strand-swap dimer interface.

Improved mammalian retromer cryo-EM structures reveal a new assembly interface

The paper improves mammalian retromer cryo-EM structures, revealing a new assembly interface between VPS26A and VPS35 N-termini.

Ubiquitination drives COPI priming and Golgi SNARE localization

The paper identifies ubiquitin recognition by COPI as essential for Golgi SNARE localization and stabilizing interactions between Arf, COPI, and SNAREs.

Diet-induced obese mice are resistant to improvements in cardiac function resulting from short-term adropin treatment

This study shows that short-term adropin treatment does not improve cardiac function in diet-induced obese mice, but reduces inhibitory phosphorylation of pyruvate dehydrogenase in cardiomyocytes.

GCN5L1 promotes diastolic dysfunction by inhibiting cardiac pyruvate oxidation

This study identifies GCN5L1 as a regulator of cardiac pyruvate oxidation, showing its role in promoting diastolic dysfunction through inhibition of PDH complex acetylation in aged obese mice.

The β-cell primary cilium is an autonomous Ca2+ compartment for paracrine GABA signalling

The paper investigates Ca2+ dynamics in β-cell primary cilia and identifies GABA-B1 receptor-mediated paracrine signaling as a localized Ca2+ signaling mechanism.

EpicPCR-Directed Cultivation of a Candidatus Saccharibacteria Symbiont Reveals a Type IV Pili-dependent Epibiotic Lifestyle

This study isolates a CPR bacterium using epicPCR and reveals its type IV pili-dependent epibiotic lifestyle and twitching motility.

The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis

This study identifies TMEM24 as a regulator of Ca2+ homeostasis by linking ER-PM contacts and mitochondrial function in pancreatic β-cells.

Computational modeling of C-terminal tails to predict the calcium-dependent secretion of ER resident proteins

The paper develops a computational method to predict ER retention sequences that can undergo secretion during ER calcium depletion by analyzing non-canonical ERS sequences.

Establishment of a closed artificial ecosystem to ensure human long-term survival on the moon

This study describes a 370-day closed artificial ecosystem experiment to test bioregenerative life support systems for long-term lunar habitation, demonstrating high material closure and system stability.