X. Zeng

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

This study identifies PA28γ's role in promoting oral squamous cell carcinoma progression by enhancing mitochondrial function through interaction with C1QBP.

Backbone-mediated weakening of pairwise interactions enables percolation in peptide-based mimics of protein condensates

The paper shows how peptide backbones enhance pairwise interactions in dilute phases but weaken them in dense phases, enabling percolation in peptide-based mimics of protein condensates.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

Mpox virus (MPXV) vertical transmission and fetal demise in a pregnant rhesus macaque model

This study infects pregnant rhesus macaques with clade IIb Mpox virus and finds vertical transmission to the fetus and adverse pregnancy outcomes.

TRIP12 governs DNA Polymerase β involvement in DNA damage response and repair

This study identifies TRIP12 as a regulator of DNA polymerase β involvement in DNA damage response and repair by controlling its trafficking and chromatin loading.

A PTER-dependent pathway of taurine metabolism linked to energy balance

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

PFKP regulates AXL-MET oncogenic and metabolic pathways in lung cancer

This study shows PFKP promotes lung cancer progression by interacting with the AXL-MET pathway, beyond its metabolic role in glycolysis.

CLSTN3B enhances adipocyte lipid droplet structure and function via endoplasmic reticulum contact

This study identifies CLSTN3B as a key protein for adipocyte lipid droplet maturation by facilitating ER-LD contacts, enhancing lipid storage and metabolic health.

Linking root-associated fungal and bacterial functions to root economics

The paper links fungal and bacterial functions in root-associated communities to root economics traits in a subtropical forest.

Un1Cas12f1 and Cas9 gene drive in HSV1: Viruses that 'infect' viruses

This study develops Cas9 and Un1Cas12f1 gene drives in HSV1 to assess gene drive efficacy and resistance, finding Un1Cas12f1 has higher conversion and lower resistance.

Nonribosomal peptide synthetases require dynamic interaction between modular domains

This study investigates the dynamic interaction between the C and A domains in NRPS modules, revealing the role of the RXGR motif in adenylation activity and its prevalence across different NRPSs.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development

The paper compares placental transcriptomes and histology between native Tibetans and Han migrants, finding sex-biased expression divergence and adaptive histological changes in male-infant placentas.

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis

This study compares the tumorigenic potential of MOLT4 and JURKAT T-ALL cell lines, finding that CCR9 overexpression enhances cholesterol biosynthesis and promotes T-ALL progression.

FIREBALL: A tool to fit protein phase diagrams based on mean-field theories for polymer solutions

FIREBALL fits protein phase diagrams using mean-field theories to analyze phase separation parameters from experimental or computed data.

Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus Macaque (Macaca mulatta) model

This study shows ZIKV can transmit vertically through fetal membranes, not the placenta, in rhesus macaques.

Transcription factor GLK2 regulates key steps of anthocyanin biosynthesis to antagonize photo-oxidative stress during greening of Arabidopsis seedlings

Spin-coupled electron densities of iron-sulfur cluster imaged by in situ serial Laue diffraction

The paper uses in situ serial Laue diffraction to image spin-coupled electron densities in a [4Fe4S] iron-sulfur cluster during light-induced redox reactions.

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

This study shows that African-lineage ZIKV infection in early first trimester causes high pregnancy loss in rhesus macaques, regardless of SIV status.

Cerebral oxygenation and cardiac output responses during short repeated sprints exercise and modulatory effect of glucose ingestion

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Cultivation of widespread Bathyarchaeia reveals a novel methyltransferase system utilizing lignin-derived aromatics

This study cultivates a Bathyarchaeia strain capable of degrading lignin via a novel methyltransferase system, suggesting its role in global anaerobic lignin remineralization.

RNAs undergo phase transitions with lower critical solution temperatures

The paper shows RNAs undergo phase transitions with lower critical solution temperatures, driven by Mg2+ and phosphate backbone interactions, and can suppress RNase P activity.

HY5 regulates GLK transcription factors to orchestrate photomorphogenesis in Arabidopsis thaliana

The paper shows HY5 regulates GLK transcription factors to control chloroplast development and hypocotyl elongation during light-induced seedling development in Arabidopsis.

Two point mutations in protocadherin-1 disrupt Andes hantavirus recognition and afford protection against lethal infection

The paper identifies two point mutations in PCDH1 that disrupt ANDV recognition and protect against lethal infection in Syrian hamsters.

Distinct Single-cell Immune Ecosystems Distinguish True and De Novo HBV-related Hepatocellular Carcinoma Recurrences

This study identifies distinct immune ecosystems in true and de novo HBV-related HCC recurrences using single-cell and bulk RNA-sequencing, revealing differences in T cell phenotypes and immune interactions that may inform immunotherapy strategies.

Gene Novelties in Amphioxus Illuminate the Early Evolution of Cephalochordates

This study identifies gene novelties in Amphioxus genomes that contribute to adaptive traits like immunity, glycolysis, and calcium regulation, offering insights into early deuterostome evolution.

Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus

This study shows African-lineage Zika virus can be vertically transmitted to rhesus macaque fetuses with a low dose, similar to Asian-lineage viruses.

Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus

This study shows that high-dose African-lineage Zika virus infection in late first trimester pregnant rhesus macaques causes frequent fetal loss.

Functional stemness-related genes revealed by single-cell profiling of naïve and stimulated human CD34+ cells from CB and mPB

This study identifies stemness-related genes in human CD34+ cells from different sources and culture conditions using scRNA-seq, revealing pathways involved in stemness maintenance and potential drug targets for HSC expansion.