Structure-activity relationships of B.1.617 and other SARS-CoV-2 spike variants
T.-J. Yang, P.-Y. Yu, Y.-C. Chang, N.-E. Chang, Y.-X. Tsai, K.-H. Liang, P. Draczkowski, B. Lin, Y.-S. Wang, Y.-C. Chien, K.-H. Khoo, H.-C. Wu, S.-T. D. Hsu
This study reports cryo-EM structures of SARS-CoV-2 spike variants and finds mutations alter conformation and glycan shield, enhance ACE2 binding, but are neutralized by three antibodies.
bioRxiv · Sep 12, 2021 · PreprintBiophysics