BiochemistrybioRxivPreprint
Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of theadrenomedullin2 G protein-coupled receptor
K. M. Babin, J. A. Karim, P. H. Gordon…·A. A. Pioszak
The paper identifies AM2/IMD as a slow off-rate agonist for the AM2R receptor, showing prolonged cAMP signaling and defining the molecular mechanism of kinetic selectivity.
DOI 10.1101/2023.01.13.523955