Author

P. Hohenstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Urbach· 2 shared B. Dekel· 2 shared J. Goldberger· 2 shared T. Kalisky· 2 shared Y. Trink· 2 shared A. D. Bins· 1 shared A. Ewing· 1 shared A. Ferrer-Vacquer· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

A. Urbach

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits

A. Krishna, A. Meynert, M. Kelder, A. Ewing, S. Sheraz, A. Ferrer-Vacquer, G. Grimes, H. Becher, R. Silk, C. A. Semple, T. Kendall, A.-K. Hadjantonakis, T. Bird, J. A. Marsh, P. Hohenstein, , D. D. Ozdemir

The paper quantifies signalling effects of CTNNB1 mutations across cancer types and finds weakly activating mutations correlate with worse prognosis in hepatocellular carcinoma.

bioRxiv · Nov 9, 2023 · PreprintCancer Biology

Characterization of alternative splicing in high-risk Wilms tumors

Y. Trink, A. Urbach, B. Dekel, P. Hohenstein, J. Goldberger, T. Kalisky

This study characterizes alternative splicing heterogeneity in high-risk Wilms tumors using RNAseq data, identifying splicing patterns linked to kidney development and EMT.

bioRxiv · Oct 30, 2023Cancer Biology

Characterization of the continuous transcriptional heterogeneity in Wilms tumors using unsupervised machine learning

Y. Trink, A. Urbach, B. Dekel, P. Hohenstein, J. Goldberger, T. Kalisky

This study uses unsupervised machine learning to characterize continuous transcriptional heterogeneity in Wilms tumors, identifying three tumor archetypes and their cellular composition.

bioRxiv · Jun 6, 2022 · PreprintCancer Biology

OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum

G. Beyrend, T. C. van der Sluis, E. T. I. van der Gracht, T. Abdelaal, S. P. Jochems, R. A. Belderbos, T. H. Wesselink, S. van Duikeren, F. J. van Haften, A. Redeker, E. Beyranvand Nejad, M. Camps, K. L. M. C. Franken, M. M. Linssen, P. Hohenstein, , R. Arens

This study shows that OX40 agonism improves PD-L1 checkpoint blockade by altering T cell differentiation, leading to enhanced anti-tumor immunity through dynamic expression of NK and chemokine receptors.

bioRxiv · Dec 24, 2021 · PreprintImmunology