A. Krishna

Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

This paper evaluates SpiD3, a novel spirocyclic dimer, showing potent anti-leukemic effects in CLL cells, including resistance to ibrutinib, by targeting NF-κB signaling and the UPR.

Active shape programming drives Drosophila wing disc eversion

The paper shows active cellular behaviors drive 3D shape changes in Drosophila wing disc pouch through spontaneous strains, validated by MyoVI knockdown.

Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits

The paper quantifies signalling effects of CTNNB1 mutations across cancer types and finds weakly activating mutations correlate with worse prognosis in hepatocellular carcinoma.

Nutrient colimitation is a quantitative, dynamic property of microbial populations

This study quantifies nutrient colimitation in microbial populations, showing it occurs in lab conditions and nature, with different effects on growth rate and yield.

Size-dependent transition from steady contraction to waves in actomyosin networks with turnover

The paper studies size-dependent contraction patterns in actomyosin networks with turnover, finding that smaller systems exhibit steady contraction while larger ones show periodic wave-like contractions.

Sporadic Diurnal Fluctuations of Cyanobacterial Populations in Oligotrophic Temperate Systems Can Prevent Accurate Characterization of Change and Risk in Aquatic Systems

This study shows that cyanobacterial populations fluctuate diurnally and across depths in oligotrophic lakes, highlighting the need for multi-timepoint and multi-depth sampling to accurately assess bloom risks.

Control of Vein-Forming, Striped Gene-Expression by Auxin Signaling

The paper investigates how striped gene expression is controlled in plants, showing that ATHB8 expression is activated in striped domains through a combination of MP activation and repression by MP target genes.

Quantifying flight aptitude variation in wild A. gambiae s.l. in order to identify long-distance migrants

The paper quantifies flight aptitude variation in wild Anopheles gambiae s.l. mosquitoes to identify long-distance migrants, finding bi-modal distributions and seasonal increases in flight activity.

GAL4/GFP enhancer-trap lines for identification and manipulation of cells and tissues in developing Arabidopsis leaves

The paper identifies and characterizes GAL4/GFP enhancer-trap lines in Arabidopsis Columbia-0 for labeling and manipulating cells and tissues during leaf development.