Author

G. Grimes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Meynert· 2 shared P. Mill· 2 shared A. Ewing· 1 shared A. Ferrer-Vacquer· 1 shared A. J. Wood· 1 shared A. Krishna· 1 shared A.-K. Hadjantonakis· 1 shared C. A. Semple· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

A. Meynert

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits

A. Krishna, A. Meynert, M. Kelder, A. Ewing, S. Sheraz, A. Ferrer-Vacquer, G. Grimes, H. Becher, R. Silk, C. A. Semple, T. Kendall, A.-K. Hadjantonakis, T. Bird, J. A. Marsh, P. Hohenstein, , D. D. Ozdemir

The paper quantifies signalling effects of CTNNB1 mutations across cancer types and finds weakly activating mutations correlate with worse prognosis in hepatocellular carcinoma.

bioRxiv · Nov 9, 2023 · PreprintCancer Biology

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.

E. A. Hall, D. Kumar, S. L. Prosser, P. L. Yeyati, V. Herranz-Pérez, J. M. Garcia Verdugo, L. Rose, L. McKie, D. O. Dodd, P. A. Tennant, R. Megaw, L. C. Murphy, M. Ferreira, G. Grimes, L. Williams, , P. Mill

This study shows that PCM1 and centriolar satellites are essential for efficient ciliogenesis by facilitating protein trafficking and remodeling of the mother centriole.

bioRxiv · Apr 4, 2022Cell Biology

In vivo modelling of patient genetic heterogeneity identifies concurrent Wnt and PI3K activity as a potent driver of invasive cholangiocarcinoma growth.

N. Younger, M. Wilson, E. Jarman, A. Meynert, G. Grimes, K. Gournopanos, S. Waddell, P. Tennant, D. Wilson, R. Guest, S. Wigmore, J. C. Acosta, T. J. Kendall, M. Taylor, D. Sproul, , L. Boulter

This study identifies concurrent Wnt and PI3K activity as drivers of invasive cholangiocarcinoma growth and shows that their co-inhibition slows tumor growth in vivo.

bioRxiv · Jul 5, 2021 · PreprintCancer Biology