Author

P. Hunold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

M. N. Hoehne· 2 shared O. van Ray· 2 shared R. Haensel-Hertsch· 2 shared A. Borowek· 1 shared A. C. Joerger· 1 shared A. Nist· 1 shared A. Singhal· 1 shared D. Drangenstein· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

M. N. Hoehne

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Activation of automethylated PRC2 by dimerization on chromatin

P. V. Sauer, E. Pavlenko, T. Cookis, L. C. Zirden, J. Renn, A. Singhal, P. Hunold, M. N. Hoehne, O. van Ray, R. Haensel-Hertsch, K. Y. Sanbonmatsu, E. Nogales, S. Poepsel

The paper reveals a mechanism by which automethylated PRC2 dimerizes on chromatin to allosterically activate another PRC2 protomer for H3K27me3 methylation.

bioRxiv · Oct 12, 2023Biochemistry

Functional diversity of the TP53 mutome revealed by saturating CRISPR mutagenesis

J. Funk, M. Klimovich, E. Pavlakis, M. Neumann, D. Drangenstein, M. Noeparast, P. Hunold, A. Borowek, D.-I. Balourdas, K. Kochan, N. Merle, I. Bullwinkel, M. Wanzel, S. Elmshauser, A. Nist, , T. Stiewe

This study uses CRISPR mutagenesis to analyze the functional impact of TP53 mutations across 9,225 variants, revealing their effects on tumor cell fitness and metastasis.

bioRxiv · Mar 10, 2023Cancer Biology

G-quadruplex DNA structures mediate non-autonomous instruction of breast tumour microenvironments

P. Hunold, M. N. Hoehne, M. Kiljan, O. van Ray, J. Herter, G. S. Herter-Sprie, R. Haensel-Hertsch

The paper identifies G-quadruplex DNA structures in breast cancer that non-autonomously instruct macrophage transcriptomes and epigenomes, promoting immunosuppression in the tumor microenvironment.

bioRxiv · Jan 16, 2023 · PreprintCancer Biology